WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such … WebAug 6, 2024 · CTGF induces the expression of inflammatory mediators and promotes cell adhesion. CTGF plays an important role in the development of glomerulonephritis by …
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WebMar 10, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes. … WebJun 1, 2016 · Age-dependent alterations in cardiac expression of adhesion molecules were suppressed in SPARC-null mice. A: gene array data of adhesion molecules. Table shows adhesion molecules, which changed with age in the left ventricle (LV) of wild type (WT) mice, including the ratio (old WT/young WT) and P value (old WT vs. young WT) of each …
WebJan 26, 2006 · 1 Introduction. CCN family protein 2/connective tissue growth factor (CCN2/CTGF) regulates cell adhesion, migration, proliferation, survival, differentiation, and gene expression in a number of cell types isolated from tissues, including chondrocytes [].CCN2/CTGF is a member of the CCN family (Cyr61, CTGF, Nov); it is strongly … WebThe extracellular matrix components involved in CTGF-regulated adhesion were determined. Recombinant CTGF was added to cells or coinoculated with gastric cancer cells into mice to evaluate its therapeutic potential. Results: CTGF overexpression and treatment with the recombinant protein significantly inhibited cell adhesion. In vivo peritoneal ...
WebCTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells. CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor … See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. Ctgf-null mice also show defects in angiogenesis, with impaired interaction between endothelial cells and pericytes … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. … See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more
WebCTGF is among the most highly expressed genes in the human TM, and it is tempting to speculate that the function of CTGF signaling in the TM involves the remodeling of …
WebMay 24, 2010 · Background Connective Tissue Growth Factor (CTGF/CCN2), a known matrix-associated protein, is required for the lactogenic differentiation of mouse … properties to rent in hanwellWebFeb 20, 2006 · 1.. IntroductionCCN family protein 2/connective tissue growth factor (CCN2/CTGF) regulates cell adhesion, migration, proliferation, survival, differentiation, and gene expression in a number of cell types isolated from tissues, including chondrocytes [1].CCN2/CTGF is a member of the CCN family (Cyr61, CTGF, Nov); it is strongly … ladies long zip front velour robeWebConnective Tissue Growth Factor. Connective tissue growth factor (CTGF) is a member of the CCN (CTGF, cysteine-rich angiogenic protein 61, and nephroblastoma overexpression gene) family of regulatory proteins. ... CTGF was originally found to promote fibroblast proliferation, migration, adhesion, and extracellular matrix formation as its … properties to rent in hartenbosWebFeb 25, 2015 · Introduction. Connective tissue growth factor (CTGF) is the second member of the CCN family of proteins which consists of six members with a similar multi-modular … properties to rent in hadleigh suffolkWebCTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial and epithelial cells, and binds to IGF, TGF-β1 and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans. ladies longer length quilted jacketWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … properties to rent in havantWebFeb 25, 2015 · Introduction. Connective tissue growth factor (CTGF) is the second member of the CCN family of proteins which consists of six members with a similar multi-modular structure [].CTGF has 349 amino acids that are divided into four modules; the first module is an insulin like growth factor (IGF)-binding domain, the second is a von … properties to rent in halifax uk