Webcrf1型受体由415个氨基酸组成,分布于整个中枢神经系统,以垂体及前额皮质为著。crf2型受体由411个氨基酸组成,主要分布在外周如心血管和胃肠道、附睾等组织,部分表达于中枢神经系统 [20,21] 。由于糖基化的不同,crf与crf1型受体的亲和力是crf2型受体的10~40倍。 WebFeb 1, 2004 · This review will update and expand these, with the inclusion of the newly discovered CRF2 family members. After presenting an overview of the receptor family, …
Cloning of murine IL-22 receptor alpha 2 and comparison with its …
WebJun 1, 2004 · IL-22 requires the presence of the IL-22 receptor (IL-22R) and IL-10 receptor 2 (IL-10R2) chains, two members of the class II cytokine receptor family (CRF2), to effect signal transduction within ... WebJun 19, 2001 · The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine. ... Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. K. Lewis, C ... buspirone 7.5 mg 2 times a day
The Class II cytokine receptor (CRF2) family: overview and …
WebUrocortin II. Urocortin 2 (Ucn2) is an endogenous peptide in the corticotrophin-releasing factor (CRF) family. [1] Urocortin II is a 38- amino acid peptide that is a member of the CRF family of peptides. Unlike Urocortin I, Urocortin II is highly selective for the CRF2 receptor and does not show affinity for the CRF binding protein. WebOct 17, 2001 · The cytokine receptor family type 2 (CRF2) comprises receptors for important immunomediators like interferons and interleukin-10 (IL-10). We identified a novel member of this family which ... WebNov 1, 2012 · Liaw et al. (1996) stated that there are 2 G protein-coupled corticotropin-releasing hormone (CRH; 122560) receptors, CRHR1 and CRHR2, which they termed the CRF2 receptor.CRH is a 41-amino acid peptide synthesized in the hypothalamus that is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an … buspirone 5 mg side effects