WebApr 2, 2024 · Major finding: CHD1 is required for the growth of PTEN-deficient prostate cancer cells in vitro and in vivo. Mechanism: PTEN induces GSK3β-mediated phosphorylation of CHD1 in the degron domain, promoting CHD1 degradation. Impact: Synthetic-essential genes may reveal druggable targets in tumors with tumor-suppressor … WebSep 2, 2024 · Consistent with previous research reporting that loss of PTEN elevates CHD1 levels, studies in a genetically engineered mouse model, patient-derived organoids, and patient samples showed that PTEN defects are associated with a better response to AURKA inhibition in advanced prostate cancer. These observations demonstrate that CHD1 …
Synthetic essentiality of chromatin remodelling factor CHD1 in …
WebApr 2, 2024 · Major finding: CHD1 is required for the growth of PTEN-deficient prostate cancer cells in vitro and in vivo. Mechanism: PTEN induces GSK3β-mediated … WebThe chromodomain motif is found among certain chromosomal proteins of all eukaryotes. The chromodomain fold – three beta strands packed against a C-terminal alpha helix – mediates protein–protein and/or protein–nucleic acid interactions. In some cases, the affinity of chromodomain binding is regulated by lysine methylation, which appears to target … free hourly employee timesheet template
CHD1 Is a Synthetic-Essential Gene in PTEN-Deficient Prostate …
WebMay 8, 2024 · The CHD1-PTEN synthetic lethal relationship may even be exploited further using immune checkpoint inhibition given CHD1's role in maintaining an elevated level of myeloid-derived suppressor cells ... WebSep 17, 2024 · CHD1 loss was detected in a similar percentage of cases with PTEN loss (25%; 11 out of 44) and cases with wt PTEN (24.1%; 14 out of 58) (Chi-square test, p = .92). 3.3 Relationship of loss of SPOP and PTEN expression, SPOP mutations, and CHD1 loss with clinical-pathological variables WebMay 1, 2024 · In a parallel study including 4986 patients with known CHD1 and PTEN status we determined the prognostic role of CHD1 loss in PTEN-wildtype vs -deleted patient subsets (Oh-Hohenhorst et al., in ... blueberry stain removal clothes